Benefits beyond your central nervous system
FORMULATED TO HELP SUPPORT
Acute Cognitive Performance + Neuronal Transmission†
Enhances immediate cognitive faculties and facilitates optimized synaptic signaling, leveraging neuroactive compounds for accelerated neuronal communication and processing speed.
FORMULATED TO HELP SUPPORT
Calm Focus + Working Memory†
Augments attentional control and working memory capacity through modulation of neurotransmitter systems, supporting an elevated state of calm concentration and cognitive retention.
FORMULATED TO HELP SUPPORT
Sustained Caffeine-Free Cellular Energy†
Provides a steady supply of cellular energy sans stimulants, through mitochondrial bioenergetics enhancement, enabling prolonged cognitive exertion without the metabolic drawbacks of caffeine.
FORMULATED TO HELP SUPPORT
Neuronal Longevity + Myelin Sheath Integrity†
Promotes neuronal health and longevity via neuroprotective agents that also maintain myelin sheath integrity, essential for the preservation of signal transmission velocity and neural circuit efficiency.
FORMULATED TO HELP SUPPORT
Cortisol Homeostasis + Decreased Perceived Stress†
Regulates cortisol levels and modulates the hypothalamic-pituitary-adrenal (HPA) axis response to stress, contributing to reduced perception of stress and bolstering of stress resilience mechanisms.
FORMULATED TO HELP SUPPORT
Insulin Efficiency†
Optimizes insulin signaling pathways, thereby enhancing glucose metabolism efficiency and supporting cognitive function by ensuring stable systemic energetics.
FORMULATED TO HELP SUPPORT
Decreased Systemic Inflammation from R.O.S. + Pro-Inflammatory Cytokines†
Mitigates systemic inflammation by neutralizing reactive oxygen species (R.O.S.) and inhibiting pro-inflammatory cytokines, thereby safeguarding neuronal integrity and promoting a conducive environment for cognitive processes.
Our Formula:
Neuroprotective and Cognitive Small Molecules†
Neuroprotective and Cognitive Small Molecules†
INGREDIENTS
L-Tyrosine | 2,000 mg
Serves as a precursor for the synthesis of catecholamines—dopamine, norepinephrine, and epinephrine—via the tyrosine hydroxylase (TH) and dopa decarboxylase enzymatic pathways, thus, enhancing cognitive resilience under conditions of stress and fatigue.
INGREDIENTS
Acetyl-L-Carnitine | 1,000 mg
Acts as an acyl moiety carrier, facilitating the translocation of long-chain fatty acids across the mitochondrial membrane for subsequent β-oxidation. It is instrumental in the generation of adenosine triphosphate (ATP) via oxidative phosphorylation and can serve as a substrate for acetylcholine synthesis, a neurotransmitter essential for synaptic plasticity, particularly in the hippocampal and cortical neurons supporting neuroenergetics and attenuating age-associated neuronal degradation.
INGREDIENTS
Alpha GPC | 600 mg
A choline-containing phospholipid that acts as a direct precursor for the biosynthesis of acetylcholine, a neurotransmitter pivotal in cognitive functions and neuromuscular signaling. It is also hypothesized to potentiate N-methyl-D-aspartate (NMDA) receptor function, a critical mediator in synaptic plasticity, learning and memory.
INGREDIENTS
Alpha-Lipoic-Acid | 350 mg
Possesses unique redox capabilities, enabling it to exist in both reduced (dihydrolipoic acid (DHLA)) and oxidized forms. This dual nature confers potent antioxidant properties and can quench a variety of free radicals and reactive oxygen species (R.O.S.) mitigating oxidative damage in neural tissues.
INGREDIENTS
L-Theanine | 100 mg
A unique, non-proteinogenic amino acid primarily found in tea leaves (Camellia sinensis). Unlike proteinogenic amino acids, L-Theanine is not incorporated into proteins but exhibits a range of biological activities. It has been shown to increase levels of gamma-aminobutyric acid (GABA) and alpha-wave activity in the brain. GABA is an inhibitory neurotransmitter that modulates neuronal excitability, contributing to calming effects.
INGREDIENTS
Phosphatidylserine | 100 mg
A phospholipid component integral to cellular membranes, particularly in the brain. It plays a role in maintaining membrane fluidity, integrity, and functionality of neuronal cells to support cognitive operations and memory formation.
Our Formula:
EMLOM® Botanical Blend
EMLOM® Botanical Blend
INGREDIENTS
Rosemary | 500 mg‡
Rich in terpenoids like rosmarinic acid, carnosic acid, and ursolic acid, which are biosynthesized via the mevalonate and methylerythritol phosphate pathways in the plant (Rosmarinus officinalis). Also, some compounds in rosemary, such as rosmarinic acid and 1,8-cineole, act as acetylcholinesterase inhibitors, thereby increasing the levels of acetylcholine in synapses to enhance cognitive performance and memory consolidation
INGREDIENTS
Sage | 500 mg‡
Phenolic compounds such as rosmarinic acid and flavonoids present in sage (Salvia officinalis) leaves have demonstrated acetylcholinesterase inhibitory activity, thereby increasing synaptic cholinergic activity for improved memory recall and attention processes.
INGREDIENTS
Lemon Balm | 500 mg‡
Compounds in lemon balm (Melissa officinalis L.), such as rosmarinic acid and flavonoids, have been shown to interact with the GABAergic system, inhibiting the enzyme GABA transaminase and thus elevating GABA levels in the brain to reduce feelings of anxiousness and promoting a relaxed state conducive to focused cognitive tasks.
INGREDIENTS
Ashwagandha | 300 mg‡
Bioactive compounds in the ashwagandha root (Withania somnifera) such as withanolides have been shown to modulate GABAA receptors, leading to increased inhibitory neurotransmission in the central nervous system. Ashwagandha demonstrates adaptogenic qualities, possibly by regulating the Hypothalamic-Pituitary-Adrenal (HPA) axis and reducing serum cortisol levels, decreasing levels of stress and support overall neuroendocrine function and mood stabilization.
INGREDIENTS
Other Ingredients
Vegetarian Capsule: microcrystalline cellulose, silicone dioxide, hypromellose
Branded® v. Generic Ingredients
Overpriced and deceptive marketing manipulation versus clinical manufacturing and why we choose generic ingredients over Branded® products.
Branded® v. Generic Ingredients
BRANDED® V. GENERIC MANUFACTURING PROCESS
Step I: cGMP Laboratory Sourcing
cGMP FDA regulated lab in the U.S.A. sources domestic and international raw materials (ingredients) to be used within a dietary supplement. i.e. L-tyrosine raw powder, sourced California, U.S.A.
BRANDED® V. GENERIC MANUFACTURING PROCESS
Step II: Dietary Supplement Co. Sourcing
Both NESIS and our leading competitors need to use the same raw material (ingredient) in our formulations and are offered a negotiated price either by mass or volume. i.e. $1/kg of raw powder.
BRANDED® V. GENERIC MANUFACTURING PROCESS
Step III: Presenting to the Consumer
However, many of our leading competitors will either (1) place this raw material (ingredient) within a proprietary blend at a non-disclosed potency to the consumer and register this ingredient though the USPTO as their "own" ingredient or (2) place this ingredient at a unique amount or conduct a "unique" test on it and register the name of this ingredient as their own "Branded®" ingredient. i.e. L-tyrosine v. Tyra-Max®
BRANDED® V. GENERIC MANUFACTURING PROCESS
Step IV: Marketing for Sales not Benefits
Companies need sales to maintain operations, however, the margins (amount of profits minus costs of goods sold in $) can be vastly different depending on the manufacturer's suggested retail price (MSRP). i.e. 500 mg L-tyrosine generic at $29 v. 500 mg Tyra-Max® at $99
BRANDED® V. GENERIC MANUFACTURING PROCESS
Why We Use Generics: Bioequivalence
We refuse to overprice our product because it has a clever ® name that we registered with a group of lawyers through the USPTO. Why? NESIS is formulated by a doctor of pharmacy (Pharm.D.) who has an expert understanding of the structure activity relationships (S.A.R.) of a molecule and the bioequivalence of generics v. Branded® ingredients. Under incredibly rare and marginal circumstances (typically with hormones or injectable biologics) there is a difference between generic v. Branded® ingredients. For dietary supplements this is simply not the case.
note: EMLOM® is not a branded ingredient. It's simply a name given to the four (4) generic botanicals at the specified potencies in NESIS INCEPTION. We are not claiming that our ingredients are miraculously different, but that our potencies are what is actually important. In other words, potency yields benefits, not a Branded® ingredient.
Our Standards
QA/QC
Third-party tested and manufactured under cGMP standards in the USA
Purity + Potency
No harmful dyes, additives, fillers or unnecessary ingredients. Only the optimal potency of each clinically-researched ingredient
†THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FDA. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.
‡ Equivalent from 500 mg of concentrated Rosemary, Sage and Lemon Balm and 300 mg of concentrated Ashwagandha extracts.
