L-tyrosine serves as a precursor for the synthesis of catecholamines—dopamine, norepinephrine, and epinephrine—via the tyrosine hydroxylase (TH) and dopa decarboxylase enzymatic pathways.*

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Acetyl-L-carnitine acts as an acyl moiety carrier, facilitating the translocation of long-chain fatty acids across the mitochondrial membrane for subsequent β-oxidation. It is instrumental in the generation of adenosine triphosphate (ATP) via oxidative phosphorylation and can serve as a substrate for acetylcholine synthesis, a neurotransmitter essential for synaptic plasticity, particularly in the hippocampal and cortical neurons.*

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Alpha-Lipoic Acid possesses unique redox capabilities, enabling it to exist in both reduced (dihydrolipoic acid (DHLA)) and oxidized forms. This dual nature confers potent antioxidant properties, as alpha-lipoic-acid can quench a variety of free radicals and reactive oxygen species (ROS).*

Alpha-lipoic-acid serves as a vital cofactor for several mitochondrial enzyme complexes, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, integral for aerobic metabolism and the citric acid cycle.*

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Alpha-GPC is a choline-containing phospholipid that acts as a direct precursor for the biosynthesis of acetylcholine, a neurotransmitter pivotal in cognitive functions and neuromuscular signaling. It is also hypothesized to potentiate N-methyl-D-aspartate (NMDA) receptor function, a critical mediator in synaptic plasticity, and learning and memory.*

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L-Theanine is a unique, non-proteinogenic amino acid primarily found in tea leaves (Camellia sinensis). Unlike proteinogenic amino acids, L-Theanine is not incorporated into proteins but exhibits a range of biological activities. It has been shown to increase levels of gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter that modulates neuronal excitability, contributing to calming effects.*

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Phosphatidylserine is a phospholipid component integral to cellular membranes, particularly in the brain. It plays a role in maintaining membrane fluidity, integrity, and functionality.*

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Rosemary (Rosmarinus officinalis) is rich in terpenoids like rosmarinic acid, carnosic acid, and ursolic acid, which are biosynthesized via the mevalonate and methylerythritol phosphate pathways in the plant. Also, some compounds in rosemary, such as rosmarinic acid and 1,8-cineole, act as acetylcholinesterase inhibitors, thereby increasing the levels of acetylcholine in synapses.*

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Compounds in lemon balm (Melissa officinalis), such as rosmarinic acid and flavonoids, have been shown to interact with the GABAergic system, inhibiting the enzyme GABA transaminase and thus elevating GABA levels in the brain. Certain constituents also display acetylcholinesterase inhibitory activity, similar to that observed in rosemary, thereby increasing acetylcholine levels.

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Phenolic compounds in sage (Salvia officinalis) such as rosmarinic acid and flavonoids present in sage leaves have demonstrated acetylcholinesterase inhibitory activity, thereby increasing synaptic acetylcholine levels.*

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Bioactive compounds in ashwagandha (Withania somnifera) such as withanolides have been shown to modulate GABAA receptors, leading to increased inhibitory neurotransmission in the central nervous system. Ashwagandha demonstrates adaptogenic qualities, possibly by regulating the Hypothalamic-Pituitary-Adrenal (HPA) axis and modulating serum cortisol levels.*

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Our clinically-researched formula is six (6) easy-swallow vegetarian capsules once daily

Honestly, you know your body best. When we were testing our formula, our users fully tolerated the recommended serving. Also, each serving has been thoroughly researched to be safe and effective at these amounts*

If you are uncomfortable starting at the full serving, we recommend the following serving schedule:

• Three (3) capsules once daily for days 1-3

• Four (4) capsules once daily for days 4-6

• Five (5) capsules once daily for days 7-9

• Six (6) capsules once daily starting on day 10

Please speak to your local pharmacist or physician to clarify. We worked very hard to ensure these ingredients have the lowest number of interactions and contraindications, however, this falls into a case-by-case basis.

We recommend taking this once daily on an empty stomach upon awakening. Taking this with your morning tea or coffee is OK.

A few of our ingredients have been shown to improve insulin sensitivity and suppress gluconeogenesis (production of glucose), therefore may lower blood glucose levels and should be monitored. It is best to speak with your primary physician helping manage your glucose levels to ensure this product is safe for you.

Please speak to your neurologist regarding NESIS supplementation. They will be able to help guide based on your specific seizure disorder (i.e. tonic-clonic, absence, etc.)

If you remember within 8 hours of your normal time to take NESIS INCEPTION, you are OK to take the missed serving.

• Example: Normal serving time: NESIS INCEPTION at 0600, remember at lunchtime, OK to take

• Example: Normal serving time: NESIS INCEPTION at 0600, remember at dinnertime, SKIP and restart regimen on the following day

NOTE: The reason we tell you to skip the serving is not because of safety issues, it's more related to the idea that you want to take NESIS INCEPTION at the start of your day when you're most alert, not when you're about to unwind and maintain good sleep hygiene.

Overall, you may start to feel the effects the first morning you take NESIS INCEPTION.

You should see a bit of a cycle at first while your body is reaching what we call a "steady state" in pharmacokinetic terms. This means your body is maintaining an equilibrium of the molecules within the desired levels.

The cycle may look something like this:

• Day 1-5: Relative and noticeable increases in your drive, endurance, memory, focus

• Day 6+: Your new baseline which may not "feel" as drastic of a change, but has become the new "flow" state for your functionality

  
  

Remember, this product is working at the cellular level, and unlike compounds like caffeine, this should not leave you with jittery jolts followed by a massive crash. The goal is an optimized state of being that is steady and sustainable

NO, there is no caffeine in NESIS INCEPTION therefore, once you reach a steady state, (see FAQ question "how long until I start to feel the effects?" for a definition on steady state) you should have a new baseline energy and efficiency at the cellular level.